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Cortisol Manager Integrative Therapeutics – Does It Really Work?

Cortisol Manager Integrative Therapeutics – Does It Really Work?

We all have different experiences when it comes to stress and how we deal with it, but one thing is for sure, we ALL experience stress. Some people more subtle than others, and in some, more internal stress is experienced than external stress. But one way or another, this “thing” called STRESS, gets in our way and as much as we do not like to admit it, it affects us. I think we are so accustomed to being stressed that we believe it is part of life and just have to accept it as such. The thing is, stress in associated to many health issues and therefore we need to develop strategies to minimize its effects. For me, stress caused major issues sleeping, and I was recommended by my naturopath to try a vitamin called cortisol manager integrative therapeutics.

I was skeptical at first but I was also desperate. Due to a combination of stress and working shift work, I could not get more than 4 hours of sleep daily. I had no issues falling asleep but rather, it was staying asleep. I decided to try cortisol manager because I had already tried a prescription sleeping pill and that was absolutely horrible. First of all, I would still wake up in the middle of the night, and still not able to fall back asleep. So instead of just being tired from only sleeping a few hours, I felt groggy and “high” on drugs.

On top of that, prescription sleeping medications can be highly addictive. Luckily, I did not get addicted, and that was probably due to the fact that it brought me no relief or satisfaction.

Before being recommended to take cortisol manager, my naturopath sent me home, to conduct a stress test over a period of 4 days, at different times of the day. It involved taking samples of my saliva, to measure the levels of cortisol (stress hormone) throughout the day.


As expected, my level of stress were higher than average, and highest when I first woke up. This suggested that instead of “shutting” down mentally at night to sleep my brain and thoughts were still in over drive.

I was causing myself internal stress, which was likely preventing me from falling BACK asleep again after opening my eyes after a couple of hours of sleep. What external stress can you possible have while cozy and safe in your bed?? Definitely not an external stress, unless there is a tornado happening outside. The stress I was having at 4am, was SELF-INFLICTED. Worrying and planning for the next day, fear of not finishing an assignment on time etc. Whatever I was thinking about, it was causing SERIOUS concern for my health.

I was confused as to why I would be able to fall asleep IMMEDIATELY when I got to bed. My naturopath explained it was because my levels of cortisol were so high ALL day, that I was emotionally and physically exhausted from the stress.

Remember, as discussed in my other article on stress, cortisol is actually a good hormone for the body. But its main function is for immediate and SHORT-TERM stress to the body – known as the “fight-flight” reaction. Its an adaptive mechanism to deal with the threat and then go back to NORMAL.

Having chronic levels of stress, which often means lots of internal stress, such as worry, fear, panic etc, will cause a cascade of effects within the body. As a result, your body is literally “yelling” and “fighting” against the over production of cortisol.


Chronically high levels of cortisol cause inflammation to the body affecting its immune system, gastrointestinal system and more. The body continuously works VERY hard to try to balance everything and to get back to homeostasis which is the HAPPY place for the body.

So now that I explained where I was at, I guess it is obvious that trying vitamins over potentially addictive and non-effective sleeping pills could only provide me with an increase in sleep and better health over all. I did not feel there was any way it would make me worse, so I gave it a go.


PRODUCT: Cortisol Manager

COMPANY: Integrative Therapeutics (American Delivery Only)

BEST PRICE: 24.99 USD (30 Tablets) or $65.00 USD (90 Tablets) with Pure Prescriptions

COMPANY: YesWellness (Canadian Customers)

BEST PRICE: $29.99 CAD (30 Tablets) OR  $81.99 with Yes Wellness

RATING: 4.8/5

Who Is Integrative Therapeutics  Integrative Therapeutics, LLC

Integrative Therapeutics, came about in 2000, through the union of 4 independent and well-established vitamin companies known as Vitaline Formulas (since 1975), NF Formulas (since 1978), Tyler Encapsulations (since 1987) and Phytopharmica (since 1981).

What makes this union unique, was not only their well-established credibility due to high quality products proven through clinical testing, but was their unique specialties:

1. Vitaline Formulas – founded by a neurological, renal and cardiovascular doctor. This company became well-known for the creation of the ground-breaking formula Vitaline CoQ10 which is still widely used today.

CoQ10 helps your cells make energy and therefore its most obvious effects is increasing your stamina. It also helps with your metabolic system, cardiovascular health, and helps your immune system.

2. NF Formulas – developed many unique herbal-based nutritional combinations that continue to be used today. It was one of the first supplement brands developed exclusively for healthcare professionals.

3. Tyler Encapsulations – is known for its dominant leadership in gastrointestinal health. Known for the digestive restoration program utilized today.

4. PhytoPharmica – known for their nutritional innovations for adrenal support and cellular immunity.

Why Believe in Their Quality?


Integrative Therapeutics admits being slower on releasing new products, because they are proud of the tedious and meticulous process they use to select their sources.  Who will provide them with the raw materials for their products is an intense and laborous task, well worth the time.

And I could not agree more!


Step 1: Potential suppliers must complete a 19-page questionnaire, detailing from beginning to end, how they make/grow their raw materials.

Step 2: Potential suppliers are required to submit a sample of the material.

Step 3: The ingredient is received by integrative therapeutics and is quarantined.

Step 4: The sample is tested to determine the identity, impurities, pesticide levels etc.

Step 5: This testing is repeated every time a material enters our facility, and at multiple points in the manufacturing process.


All the products developed by Integrative Therapeutics are clinically and scientifically driven. They have an in-house laboratory with over 30 scientists and a medical advisory board, comprised of various different health professionals.


The reason I really prefer integrative therapeutics over other vitamins is because it is one of the few companies that sets their standards to a high level, for dietary supplements and over the counter modifications.

This means that their products are AUDITED by the drug GMP (good manufacturing practices).


This is one of the most controversial topics when it comes to vitamins.

Most labels for vitamins make claims to how much of each ingredient there is or what it “MAY” contain, to protect themselves from allergic reactions from users.

Since everything in the bottle manufactured by integrative therapeutics is HUMAN-TESTED, what it claims on the bottle is a PROMISE, and it will clearly PROMISE which allergens it DOES NOT contain vs. “may” contain.



Ingredients and Their Role

1. Phosphatidylserine

Lots of “fitness” and “health” oriented people may known what this is because it is often added to protein shakes and/or other post-workout drinks, because it helps with the repair and healing of muscles.

In more “scientific” terms, it is a fatty substance and is the key component of your cell membranes. It helps cover and protect the cells and allows for communication between cells. It is also shown to be very important for cognitive functions and memory.

So how does it help with stress? As cell membranes, they block high levels of cortisol reaching the cells and to prevent damage. This can massively reduce the negative effects of cortisol on the body.

This is the perfect place for me to mention, that I typically try to avoid vitamins if I can manage to get sufficient quantities through natural foods. But another reason would be if the natural foods that provide the vitamin is let’s just say, not overtly appetizing…

For instance, in which foods can you find Phosphatidylserine?? In chicken hearts and pig kidney. And the highest dose by far is in bovine brain. Now if you ask me, you can try to PAY me to at these and I will refuse.

Yup…that’s my face just below haha


Good news there are a couple of more commons foods to find phosphatidylerine: Mackerel and herring fish.

DOSAGE recommended: 300 milligrams to 800 milligrams a day is absorbed well by humans.

There are many clinical studies that confirm the important role that phosphatidylerine plays in helping with stress levels.

Studies also show that 600 mg per day for 10 days, blunts the cortisol response to exercise-induced stress and significantly increases the testosterone to cortisol ratio. This means that Phosphatidylserine is an effective supplement for combating exercise-induced stress. (1)

According to Diagnostechs:

“Supplemental PS may be most beneficial for chronically stressed individuals who exhibit elevated cortisol on testing and who also suffer from anxiety, depression, or cognitive decline. PS may also help normalize cortisol output in chronically stressed patients who have low cortisol levels on testing. Additionally, PS is particularly indicated for athletes who aim to optimize performance and speed recovery after intensive training. Overall, supplemental PS can be a valuable tool for regulating the stress response in patients of all ages and fitness levels.”

2. Aashwagandha (Withania somnifera)

Studies have shown that Ashwagandha is best known for its stress-lowering effects.

For instance in one study with 60 healthy adults taking 240mg of aashwagandha daily, showed a significant decrease in anxiety, depression and cortisol levels compared to the control group. (2)

Other study showed that daily doses of 125 mg to 5 grams for 1–3 months have shown to lower cortisol levels by 11–32% .

In summary Ashwagandha has several health benefits, such as improved blood sugar, inflammation, mood, memory, stress and anxiety, as well as a boost in muscle strength and fertility. It can be taken to help all of these issues, but regardless of what you are taking it for, the dosage will change. Overall 250–500 mg per day for at least one month seem effective.

3. L-theanine

Tea Bag-Ltheanine-StressRelief

L-theanine is an amino acid found in green and black tea leaves which has relaxing effects in humans and animals.

One study showed that intake of L-Theanine results in a reduction in heart rate responses to an acute stresses.(3)

According to ZRT Laboratory research:(4)

-L-theanine can be administered in supplement form or in tea (there is approximately 25 – 60 mg of L-theanine in tea).

– L-theanine readily crosses the blood-brain barrier within 30 minutes and continues to increase, reaching maximum levels after approximately 5 hours.

-Typical dosing for supplementation starts at 200 mg of L-theanine every 4-6 hours.

4. Magnolia


Magnolia is a plant and the bark and flower buds are used to make medicine and it is native from China.

Magnolia contains bio active compounds that function as anti-inflammatory, anti-bacterial, and anti-allergic agents. Among most well-known and well-studied of these compounds are honokiol and magnolol.

The cortisol manager by integrative therapeutic that I am highly recommending, contains these two most studied compounds of magnolia. More specifically, it contains 2% honokiol and 1% magnolol and epimedium.

Dr. Michael Breus wrote an article, summarizing the effects of this powerhouse plant, that has been used for centuries:

-Reduce anxiety

-Help with sleep

-Reduce inflammation

-Reduce pain

-Reduce adrenaline (another stress hormone)

-May help with weight gain and insulin resistance

-May kill cancer cells

Dr. Michael Breus also stated that magnolia bark supplement doses are 200-400mg depending on the type of conditions trying to be treated and the weight of the person.

WARNING FOR PREGNANT OR BREASTFEEDING. According to WedMD, taking magnolia flower bud by mouth is UNSAFE during pregnancy. There are reports that magnolia can cause the uterus to contract and that might cause a miscarriage.

Should You Take Cortisol Manager?

I can speak for myself, that after taking cortisol manager integrative therapeutics for just one month, I saw a huge difference in my sleep pattern. I would wake up less in the middle of the night and when I did wake up, I was able to fall back asleep.

Sleeping well, resulted in an increase in my quality of life. I was more patient, less irritable, and less stressed throughout the day as well.

Looking at reviews of this product, I can promise you the results were not a “coincidence” for me. There is no site that sells this product, where the average review rating was below 4.5 star. In fact, the overall rating is 4.8 to 5 star. And believe me, I looked at MANY sites.

Here are a few screenshots of reviews from different on-line companies, selling this product.

Review 1-cortisol-manager-integrative-therapeutic

Review 2-cortisol-manager-integrative-therapeutic

Review 3-cortisol-manager-integrative-therapeutic

Review 4-cortisol-manager-integrative-therapeutic

Final Thoughts

If you have concerns of taking any type of dietary supplements, that is totally fine and you should always discuss these concerns with a professional if that is the case.

I am very confident of the quality of the raw ingredients used to make these supplements. I am also satisfied with the role of each of these ingredients which have been wisely selected by integrative therapeutics, to produce this supplement. It has been shown time and time again through CLINICAL research, that each of these ingredients on their own, have a natural and positive effect on health.

TOGETHER, these ingredients have proven to be significantly powerful.

I have taken a handful of vitamins in my life, because as I have mentioned before, I prefer trying to get all my vitamins and minerals through food. And of the supplements I have taken in the past, this one is HANDS DOWN, the ONLY one that had a visible and obvious POSITIVE impact in my life.

What I think is even more important, is that it does not cause any dependency. I stopped using it after approximately 6 months, and my sleep continued to stay consistent.

I took cortisol manager again in my life, when I was going through a very stressful time, and it was not for my sleep quality but rather for daily anxiety. Again, this supplement worked wonders and again, I did not have to use it forever and I did not have a hard time stopping to use it because an addiction will not develop.

If you feel overly stressed and anxious, and you have difficulty sleeping, and want to try cortisol manager integrative therapeutics, don’t wait any longer, buy it at Pure Prescriptions if you need delivery to the USA or YesWellness if in Canada.

Please let me know if you have tried this before or if you decide to buy it:) Give me your feed back or let me know of products that you have tried, bad or good ones so I can share with other women:)

Cortisol Manager

29.99 CAD

Overall Product




Customer Satisfaction



  • Quality of Raw Ingredients
  • Clinically proven
  • Non-addictive


  • Results require on average 3 months
  • Results may vary individually

8 thoughts on “Cortisol Manager Integrative Therapeutics – Does It Really Work?”

  1. Thank you for posting this very detailed and interesting article. Stress can be something very difficult to manage and while I try not to take any pills or drugs, sometimes it becomes necessary. Some people really can’t fall asleep, no matter how hard they dry and products like this can really help them. 

    • Hello Horatius,

      Thank you for your comment and taking the time to read my article. 

      I too, hope that this supplement will be utilized for people who really need it because it does not camouflage the problem, it really helps and eventually you can resume life without it. So for people like you and I who prefer not taking vitamins or supplements, it is a very good option!

      Thank you for reading and take care.

  2. This is a subject after my own heart. I can relate totally to how you describe your nights sleep. I too wake up after a couple of hours and then the brain starts. I think of what I will do and how I will do it the next day. I start to make plans of what I will do first etc., Whatever I do, I cannot calm my overactive brain. I have had this condition for over half my life and if I don’t sort it out, I fear my life will be shortened. Now COVID 19 is a world wide problem, I worry so much about my family, especially as I cannot be with them at this testing time. I was getting to grips a little with my sleeping problems but the virus has put paid to that!

    Of all the conditions I have had, insomnia is the one I cannot seem to completely alleviate. I don’t take any pharmaceutical drugs, just the vitamins and minerals that I know I am deficient in, particularly magnesium. As I’m on the wrong side of 70, I also take liposomal vitamin C which I hope will keep me safe, even if I do get the virus. But if I could only get this sleeping problem sorted out, I think I will be as fit as I could be for someone my age. Thanks for a great post. I would pursue this further if I lived in the US!

    • Hello Ches,

      Thank you for sharing your experience with sleep and stress. Sounds like you and I shared a very similar experience but it looks like you are still dealing with this currently and this is no good. 

      Where do you live? I am sure I can find a site that will ship internationally. I will look for you. Please let me know.

      I can really sense from your comments that this situation is brutal for you and you are right; waiting toolong to find a way to diminish the effects of stress can really affect longevity. I too accepted that the lack of sleep was fine for a long time because I continued to function well at work, I accepted the situation and because I do not like taking medication, that was the last thought in my mind. I am very grateful for my naturopath.

      I know this product can really help you so let me know what country you are from and I will do my best to locate and option.

      Thank you for reading and I am hoping we can get you to sleep better soon:)

      Sweet it’s Published! View on my Site 

  3. It is always good to read a product reciew by someone who has tried it. It looks like an excellent supplement. Over a year ago I also had trouble sleeping. Like you, I had no trouble falling asleep, but I always woke up in the middle of the night and could not go back to sleep. My brain was just whirring and whirring and would not shut up. I went to work tired and exhausted from the lack of sleep. I did not understand why this was happening because I had been an excellent sleeper all my life. If I had only known about cortisol manager Integrative Therapeutics back then. I was getting desperate. 

    Now that I read your article I understand why it was happening. I was under a lot of strees, much of it was external, but it was also internal. In the end my sleeping pattern got better. I still wake up sometimes, but now I can go back to sleep right away.

    I hope I don’t have to go through this again (I understand your pain 😉 ) but at least now I know about this supplement. I’m happy I read this. Is this only available for US and Canada?

    • Hello Christine,

      Thank you for sharing your experience with sleep and stress. Sounds like you and I shared a very similar experience. It can really be brutal and I know I waited too long before I really accepted that the lack of sleep was unhealthy. Just because I continued to function well at work, I accepted the situation and because I do not like taking medication, that was the last thought in my mind. I am very grateful for my naturopath.

      I hope that this supplement will be utilized for people who really need it because it does not camouflage the problem, it really helps and eventually you can resume life without it.

      Where do you live? I am sure I can find a site that will ship internationally. I will look for you.

      Thank you for reading and I am glad you sleep better now as well:)

  4. Very good detailed review. I have had problems with stress, and at different times suffer severe bouts of depression. It does have a lot to do with sleep. I used to work most of the night and sleep through the day, which as you know, can be near impossible to get more than 4 or 5 hours of quality sleep. 

    I hope this review on Integrative Therapeutics helps many others with sleep problems.

    • Hello Michael,

      Thank you for sharing your experience with sleep and stress. It can really be brutal and I know I waited too long before I really accepted that the lack of sleep was unhealthy.

      I hope that this supplement will be utilized for people who really need it because it does not camouflage the problem, it really helps and eventually you can resume life without it.

      Thank you for reading and I hope you sleep better now as well:)


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